E ISSN: 2583-049X

International Journal of Advanced Multidisciplinary Research and Studies

Volume 3, Issue 4, 2023

Evaluation the Cytotoxic Effects of Cisplatin on a Human Lung Cancer Cell Line A549

Author(s): Ali Naser Zubaidi AL-Baldawi, Hiyame Abdul Ridah AL-Awade


Millions of people worldwide lose their lives to lung cancer, which is an international health issue. As a result, it has drawn the attention of several researchers from all over the world, and everything related to this condition in terms of changes, whether physiological or immunological, before and after therapy, has been studied. In the present investigation, six different chemotherapeutic doses were utilized, ranging from (31.25-1000 µg/ml) over (48) hours of exposure, to assess the cytotoxic effect of cisplatin on the human lung cancer cell line A549. In the results of the current study showed the highest rate of cell inhibition was at the concentration (1000) μg / ml, as it reached about (70.400), while at a concentration of (31.25) μg /ml, cell inhibition was at its lowest rate, which was (19.60), and the results also showed that cisplatin had anti-lung cancer activity at an inhibitory concentration of half the number of cells used in the experiment (IC50), as it was about (43.75) μg/ml. The results of the current study showed that there was a significant increase (P<0.05) in the six concentrations of cisplatin when compared with control cells.

Keywords: Cisplatin, Lung Cancer, A549

Pages: 1221-1224

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