E ISSN: 2583-049X

International Journal of Advanced Multidisciplinary Research and Studies

Volume 3, Issue 4, 2023

Bioanalysis of the Rivaroxaban and Amlodipine in Dosage Forms and Spiked Plasma Using UPLC

Author(s): D Alnohy, S Morshedy, G Omran, M Mabrouk, W Talaat


The current research provides a bioanalytical technique for the analysis of definite co?administered drugs utilized for medication of nonvalvular atrial fibrillation. These studied drugs are rivaroxaban and amlodipine. The analysis was conducted by reversed-phase high-performance liquid chromatography utilizing Microsorb-MV 100-3 C18 column from Agilent Technologies (Netherlands; 100 mm 4.6 mm, 5 m) at room temperature with UV detection at 250 nm. Methanol, acetonitrile, & 10 mM sodium phosphate buffer (pH 3.6) made up the mobile phase, which had been pumped at a flow rate of 1.0 mL/min. Over 2 medicines' concentration range of 5–50 g/mL, the calibration curve had been linear. the proposed technique had been effectively used to analyze these medications in dose forms & in plasma samples that had been spiked.

Keywords: Rivaroxaban, Amlodipine, Dosage, UPLC

Pages: 249-254

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