A Review: Hepatoprotective Potential of Flavonoid-Rich Fraction from the Roots of Lantana Camara Against Paracetamol-Induced Liver Injury

Liver disorders continue to represent a significant global health challenge and contribute considerably to illness and death worldwide. Drug-induced liver damage, especially following excessive paracetamol intake, is a major clinical concern due to oxidative stress and injury to hepatocytes. In recent years, medicinal plants have attracted growing scientific interest as natural sources of hepatoprotective compounds because they contain a wide range of biologically active constituents.

Lantana camara is a common medicinal plant that contains numerous therapeutically important phytochemicals, including flavonoids, phenolic compounds, triterpenoids, and alkaloids. Among these, flavonoids exhibit strong antioxidant properties and may protect liver cells against oxidative damage.

The present review summarizes the available literature on the hepatoprotective capability of flavonoid-rich fractions obtained from the roots of Lantana camara against paracetamol induced liver injury. Particular attention has been given to the plant's phytochemical composition, the mechanism of paracetamol-mediated hepatic damage, and the contribution of flavonoids to protection against oxidative stress. The review also considers potential mechanisms by which flavonoids may act beneficially, such as reducing lipid oxidation, counteracting reactive oxygen species, and augmenting endogenous antioxidant defenses.

Available evidence suggests that flavonoid-rich root fractions of Lantana camara may serve as promising natural hepatoprotective agents. More scientific studies might help to establish their role for the prevention and therapeutic management of liver damage caused by drugs.