Role of Some Medical Plants in Gastric Ulcer Healing

A significant portion of the gastrointestinal tract, especially in birds and mammals, is the stomach. Numerous variables, including inflammatory disorders and steroidal and non-steroidal anti-inflammatory medications used to treat a variety of illnesses, can result in gastric ulcers. Gastric ulcer aetiology is dependent on intricate interplay between aggressive and protective variables. Ulcers can develop when protective factors like sufficient mucosal blood flow, the mucosal bicarbonate barrier, endothelial cell regeneration, and ongoing prostaglandin production are outweighed by aggressive factors like gastric acid, pepsin, and reactive oxygen species. Herbs and plants are used in traditional medicine to cure and prevent a variety of gastrointestinal conditions, including peptic ulcers, without causing any negative side effects. including the anti-inflammatory activity of chamomile flavones and peptic ulcers without any negative side effects. It has been demonstrated that consuming foods high in polyphenols, such as olive oil, significantly reduces the production of hydroxyperoxides. Alpha-bisabolol reduces the proteolytic activity of pepsin by 50%. Some of these actions are crucial in the healing of the ulcers. One method in the prevention and treatment of gastric ulcers is to suppress the rate of gastric acid secretion. Raw honey has an inhibitory effect on gastric acid secretion. It is widely known that prostaglandin E2 protects the stomach mucosa from the damaging effects of gastric acid, and it has been demonstrated that rosemary extract increases prostaglandin E synthesis. Sesamol may have a protective effect on gastric mucosal damage in part by preventing mucosal ROS and the ensuing lipid peroxidation.