Behçet’s Disease Beyond the Triad: Unusual and Atypical Presentations

Behçet’s disease (BD) is a chronic, multisystem, autoinflammatory disorder classically characterized by recurrent oral ulcers, genital ulcers, and uveitis. However, atypical presentations including vascular thrombosis, pulmonary artery aneurysms, gastrointestinal lesions, and neurological involvement can precede the classic triad, making early recognition challenging. We report three unusual cases: (1) a 38-year-old male with multisite vascular thrombosis, (2) a 39-year-old female with pulmonary artery aneurysms, and (3) a 30-year-old male with parenchymal neuro-Behçet’s disease. All cases required multidisciplinary management and early immunosuppressive therapy to prevent life-threatening complications. These cases underscore the importance of high clinical suspicion and thorough investigation in patients presenting with atypical symptoms suggestive of BD.