Evaluation of the alterations of Calcium and Magnesium levels in Alloxan-Induced Diabetic Rats

This study determined the level of magnesium and Ca2+ in diabetic control and Non diabetic control DM in a total of twenty (20) albino rats; diabetic (n=10) and Non-diabetic (n=10). Plasma magnesium and calcium were analyzed using indirect method of atomic absorption spectrophotphotometer. The body weight of diabetic and non-diabetic rats of the initial weight were comparable 150.3±21.9g vs 149.1±16.9g; P>0.05; the former had significantly (P<0.05) final body weight were lower (141.4±13.7) then the initial body weight of the non-diabetic control (164.1±22.3g).The fasting plasma magnesium and calcium levels were between non diabetic and diabetic rats shows that diabetic rats had lower level of plasma calcium (37.5 ±19.3ppm), and magnesium (17.0±7.7ppm) in compassion to the non-diabetic control 49.8±38.4ppm and (18.6±9ppm) for calcium and magnesium respectively. Due to difference is the selection of subject or study design and due to prevalence of diabetes in this part of the world and not much work have been done to ascertain the relationship between trace-element (magnesium and calcium) in clinical status of patient with diabetes mellitus from this work, the pattern of change is plasma magnesium and ca’ levels were similar in diabetic albino rat Clear to understand that in diabetic patients this tract element are reduced. Even though the work is consistent in some aspects with previous finding, additional and more reliable work using advance technique should be carried out with lagers number of sample in order to fully elucidate the relationship between magnesium and calcium.