E ISSN: 2583-049X
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International Journal of Advanced Multidisciplinary Research and Studies

Volume 5, Issue 1, 2025

Targets and Role of Natural Products in the Prevention of Breast Cancer: Comprehensive Review



Author(s): Mesta Shreya, Shetti Priya, Chougala Ankita, Patil Spoorti, Mane Deepa

DOI: https://doi.org/10.62225/2583049X.2025.5.1.3623

Abstract:

Over 2.3 million new cases of breast cancer were reported in 2022, and the disease claimed 670000 lives. It ranks as the main cause of cancer-related deaths among women across the world. The prevalence continues to increase with significant improvements in early detection, such as mammography, treatment such as radiation, chemotherapy, and surgery. Patients with BC often suffer from psychological distress like anxiety, depression, and mental retardation, which makes treatment outcomes more difficult. Despite being productive, traditional medicines can have serious drawbacks and adverse effects, such as poor response rates and multidrug resistance. They were investigating alternative therapies, mostly those derived from natural substances. Bioactive substances bent from plants, like terpenoids, alkaloids, flavonoids, and phenolic acids have demonstrated potential in preventing BC cells from proliferating and spreading. These substances produce anticancer effects through various pathways, including apoptosis induction, cell cycle arrest, autophagy activation, and angiogenesis restriction. Prominent plant species studied for their potential as BC treatment include Carica papaya, Corindrum sativum, Aegle marmelos, Allium sativum, and Cocos nucifera, which have been investigated for their therapeutic potential against BC. These plants contain active constituents such as papain, flavonoids, alkaloids, and organosulfur compounds, demonstrating anticancer properties in preclinical models. This review highlights the therapeutic potential of these natural compounds, their mechanisms of action, and the need for further research to validate their efficacy in human clinical trials. The findings suggest that integrating plant-based therapies with conventional treatments may offer new routes for improving breast cancer prognosis and patient quality of life.


Keywords: Breast Cancer, Anticancer, Active Components, Therapeutics

Pages: 98-106

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