International Journal of Advanced Multidisciplinary Research and Studies
Volume 4, Issue 5, 2024
Effects of Ethanol Terminalia catappa Leaf Extract on Serum Reproductive Hormones in Poloxamer-induced Hypercholesterolemia in Wister Rat
Author(s): Nyeche Smart Chigoziri, Okpara Onyedikachi Martins, Ogunleye Adekunle Solomon, Egeonu Kelvin Kelechi, Ijezie Ozioma Alberta, Anosike Glory Chinaza, Njoku Perfect Izuchukwu, Nwazue Ernest Kelechi, Chukwuemeka Famous, Dennis Arinze Nwachukwu, Sunday Chukwuebuka Wisdom, Onyishi John Chinweike, Owusu Precious Adwoa, Ogbodo Loveth Chisom, Abarigu Priye Gift, Eluu-Vincent Victoria Ugo, Okezie Priscilia Ozioma, Okolo Kenechi Samuel, Eze Precious Chizaram, Nsionu Kosisochukwu Winifred, Eze Brendan Akobundu, Agbowu Ifeoma Blessing, Chikere Emmanuel Ugonna
Abstract:
This research work was carried out to evaluate the effects of ethanol extract of Terminalia catappa, on sexual hormones following poloxamer-induced hypercholesterolemia in Wistar rat. Thirty- five (35) Wistar female rats were used for the study following an acclimatization period of 7 days. The rats were randomly divided into 5 groups of 7 rats each. Group A: Was fed with normal chow and distilled water and served as Normal Control. Group B: Was induced with 1.0g/kg dose of P-407 without treatment negative control. Group C: Were induced with 1.0g/kg dose of P-407 and treated with atorvastatin (ATV) at 20mg/kg as served as positive control, Group D: Was induced with 1.0g/kg dose of P-407 and treated with leaves extract (HLE) 100mg/kg for 14days. Group E: Was induced with 1.0g/kg dose of P-407 and treated with leaf extract (HLE) at 200mg/kg for 14days. The dose regimens were administered once daily for the period of the study. The rats were monitored for clinical signs and death. The results reveal that there was a significant (P<0.05) increase in serum oestrogen, progesterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) when compared with the normal, standard and hyperlipidemic control. Contrastingly, there was a significant decrease (P< 0.05) in serum testosterone and prolactin (PRL) when compared to the normal and standard control. It can be inferred from this present research work that the extract may stimulate or regulate ovulation and promote sexual health and drive possibly due to the presence of phytonutrient or phytoandrogens.
Keywords: Terminalia Catappa, Reproductive Hormones, Poloxamer, Hypercholesterolemia
Pages: 372-377