Molecular Docking, I.R Characterization and Biological Investigation of New Schiff base Compounds Synthesized between Sulphanilic Acid with (Phenylalanine, Asparagine, and Arginine)

New Schiff base compounds were prepared by reactions between Sulphanilic acid with different amino acids (Phenylalanine, Asparagine, and Arginine).The synthesized Schiff compounds were showed antibacterial and antifungal activities, Schiff base (Arginine, Asparagine and phenylalanine) of the tested products revealed significant antimicrobial effect against bacteria, In general, the antimicrobial activity for the Schiff base products was more effective against Gram-positive than Gram-negative bacteria strains. Some of physicochemical properties were calculated and revealed H-bond donors and acceptors to construct activity, also the properties of absorption, molecular weight, molecular formula, surface area and rotatable bonds. In addition, the interactions between the synthesized compounds were estimated by using docking protocol, also the types of interactions as H-Bond, Vander Waals and Carbon H –Bond were recorded different of the synthesized compounds.