Association study from Tight Junction Protein-1 gene SNV rs2291166 with the metabolic parameters from Fitness in body building from Oaxaca, México

Background: Considering that the TJP1 (tight junction protein type 1 gene) allele variant translate 1334-aminoacid change asp [GAC] >ala [GCC], SNV rs2291166 of which has already been associated with albuminuria and other biochemical markers of cardiovascular risk, such as HOMA index. Aim. The main objective was to investigate the relationships of the genotypes of the genetic variant SNV rs2291166 of TJP1 gene with metabolic and biochemical fitness parameters in in body building subjects. Method and subjects. 1014 Adult in body building patients were included in the study. Single nucleotide variation (SNV) genotyping was performed by chain reaction of the allele-specific polymerase. Biochemical parameters were performed using by direct photometry. Results. The glycosylated hemoglobin A1C levels were lower in homozygous G carriers. The carrier’s heterozygote, have increased systolic tension levels and body mass index. Conclusion. The SNV rs2291166 from TJP1 gene is a genetic marker that influences the factors of cardiovascular risk in body building.