A Review on Bottlebrush Prodrug: Synthesis, Characterization and Applications

Prodrugs are engineered so as to get activated in disease or tumour tissue rather than normal tissue. Prodrugs have high tumor suppression effectiveness good intra-tumoral permeability, and good circulation stability in tumor, all of which are helpful for the creation of next-generation nanomedicines for more effective chemotherapy. The most important characteristics of novel nanotherapeutic platforms are that they are able to avoid blood elution, enter and consolidate in deep tumoral tissues, and start selective drug release. Polymer-based nanotherapeutics can react to the tumor microenvironment and have a great therapeutic effect because they have stable or adaptable chemical structures and excellent biocompatibility. Bottlebrush polymers (BBPs) is a fascinating class of materials with a wide range of uses, including energy storage, biomedical devices, super soft elastomers, organic optoelectronics, templates for grafting one-dimensional (1D) nanomaterials, targeted drug delivery in tumor tissues, and organic optoelectronics. By utilizing modern synthetic techniques, this makes it possible to design BBPs with controlled dimensions, compositions, and architectures. This review aims to provide a comprehensive and critical summary that highlights the recent advances in bottlebrush prodrugs in terms of their controlled syntheses techniques, self-assembly, properties, characterization and applications.