The Protective Effect of Natural Honey against Acetamenophen-Induced Acute Pancreatitis

The therapeutic properties of natural honey is important in the protection against acute and chronic diseases. The aim of this work was to study the protective effect of natural honey against acetamenophen-induced acute pancreatitis. A total of 20 male albino wistar rats were divided into four groups. Group. A animals served as control group and were not given any treatment. Group B animals received a single dose of acetamenophen (750 mg/kg, i.p) before treatment with administration of natural honey (15ml/kg) for 7 consecutive days. Group C animals received a single dose of acetamenophen (750mg/kg, i.p) before treatment with N-acetylcystein (600mg/kg, oral) for 7 consecutive days. Group D received a single dose of acetamenophen (750mg/kg, i.p) alone. Pancreatic enzyme (amylase and lipase) tests were done and the results revealed that single dose administration of acetamenophen (750mg/kg, i.p) showed significant drug-induced acute pancreatic injury (P< 0.01) when compared to the negative control (group D). However, treatment with natural honey (15ml/kg) for 7 c0nsecutive days demonstrated substantial pancreatic protective effects than N-acetylcysteine (600mg/kg, oral). Therefore, it could be concluded that honey via its antioxidant properties has the ability to protect against acetamenophen-induced acute pancreatitis.