Preparation and Physicochemical Properties of Transdermal Patch Bases using Chitosan Matrix

Transdermal patches are a dosage form with several advantages, such as being easy to use, no external contamination, and no residue. One of the critical components in making transdermal patches is the polymer used as the base of the patch. This polymer will influence the release of the drug from the transdermal patch. The investigation of the physicochemical properties of transdermal patches can involve organoleptic, weight uniformity, pH, patch thickness, and patch fold resistance tests. In this study, the transdermal patch bases have been successfully prepared using chitosan polymer with various concentrations of 1, 1.5, 2, 2.5, and 3% w/v (F1, F2, F3, F4, and F5, respectively). Based on the evaluation of the physicochemical properties, F1 and F2 with 1.5 % and 1.5 % w/v chitosan met all parameters of physicochemical properties.