E ISSN: 2583-049X

International Journal of Advanced Multidisciplinary Research and Studies

Volume 3, Issue 5, 2023

Biochemical Changes in Liver Enzymes in Patients with Thyroid Dysfunction

Author(s): Adil Mohammed Hashim, Raheem Tuama Al Mammori, Ali Mohammed Abd-Alameer


The process of metabolising thyroid hormones is primarily regulated by the liver. In order for the liver to work properly, thyroid hormone levels must be normal. All cells, including hepatocytes, are subject to thyroid hormone regulation of their basal metabolic rate. Liver function may be affected by thyroid disorders. The current study's. Objectives are to identify the biochemical changes in liver function tests, which are aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP), in people with thyroid dysfunction (both subclinical and overt hypothyroidism), as well as assess the impact of changed thyroid hormones on these tests. Methodology The sample was tested for alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase (AST) using the calorimetric method and standard reagent kits. To measure the levels of serum T3, T4, and TSH, ELISA kits were employed. Data analysis was done. Results The results of our study show that serum levels of ALP, AST, and ALT were greater in hypothyroidism patients as compared to controls controls. Conclusions Patients with thyroid impairment have a regular correlation with the liver enzyme biochemical parameters examined.

Keywords: Hypothyroidism, Liver Function Tests, Free T3 and T4, TSH, ALP, AST, ALT

Pages: 849-852

Download Full Article: Click Here