E ISSN: 2583-049X

International Journal of Advanced Multidisciplinary Research and Studies

Volume 3, Issue 5, 2023

Accurate and Rapid Spectrophotometric Method Development for the Determination of Loratadine Drug Using O-Phenylenediamine by Oxidative Coupling Reaction

Author(s): Asmaa Ahmed Mohmmed AlAhmed Al-Rashidy


New simple, sensitive and accurate spectrophotometrice methods were developed for determining loratadine (LOR) drug in both pure forms and pharmaceutical preparations. The reaction depended on the oxidative coupling with O-Phenylenediamine via KIO3 in acidic solution to create an orange-colored product that was stable and soluble in water with a maximum absorption at λ=453 nm. Linearity ranges of LOR were (1- 30 μg.mL-1), the value of molar absorptivity was (11065.31 liter/ mol.cm) and Sandell’s sensitivity was 0.0346μg/cm2. As for the detection of limit (DOL) and quantification limit (DQL), they were (0.114 μg / mL) and (0.346 μg / mL), respectively. The results indicated that there were no interferences of excipients on the determination of LOR. The suggested method was successfully applied for the determination of LOR in pure and pharmaceutical formulations.

Keywords: Loratadine, O-Phenylenediamine, Potassium Iodate, Pharmaceutical Formulations

Pages: 29-34

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