Increase Serum Copper Level in Betel nut Chewer Oral Submucous Fibrosis Patient

Oral submucous fibrosis (OSMF) is a precancerous condition of the oral cavity and categorized as potentially malignant disorder. Trace elements such as Copper, Iron, and Zinc play an important role in growth and maintaining the integrity of cells and tissues related to oral mucosa. The aim of the present study was to examine the Serum Cu level in OSMF patients. This case-control study was carried out on 10 patients. OSMF patients were categorized by clinical and histopathological presentations and clinical staging. Flame Atomic Absorption Spectrometry was used to measured Serum copper level. Mean serum copper concentration was greater in study group compared to control group. The difference between Serum copper levels was statistically significant. Copper level was increased in OSMF patients and a gradual rise in copper level was noted with the advancement of clinical staging of OSMF who has exclusive history of betel nut chewing.