A Study of Histopathological Effects of Gentamicin Drug on Placenta of Pregnant Rats

The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2022 and February 2022, fifteen female Albino Rats are used. Gentamicin is aminoglycoside antibitics widely used during pregnancy for treatment the infections. The present study has been intended to show the histolopathologiacl effects of gentamic in on placenta in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given inta peritoneal injection of physiological normal saline and the second and third group are given inta peritoneal injection of gentamicin doses twenty, forty mg/kg/day respectively for 20 days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 20 th (dpc) to study the hitopathological effects of gentamicin on placenta. The histopathlogical study of female rats embryos treated with twenty, forty mg/kg/day of gentamicin have shown degeneration of spongiotrophoblast and congestions in placental labyrinth compare to control group.The scanning electron microscope study show deformation of architecture structure of placental parenchyma. In conclusion; gentamicin caused hitopathological effects on placenta in 20 th (dpc).