E ISSN: 2583-049X
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International Journal of Advanced Multidisciplinary Research and Studies

Volume 3, Issue 2, 2023

Diagnostic Accuracy of Neutrophil to Lymphocyte Ratio to Differentiate Gangrenous from Non-Gangrenous Appendicitis Keeping Histopathology as Gold Standard



Author(s): Dr. Nizam Ud Din, Dr. Mubashir Hassan, Dr. Muhammad Ayaz, Dr. Asim Junaid, Dr. Ubaid Ullah, Dr. Yasir Hakim

Abstract:

Objective: To determine diagnostic accuracy of neutrophil to lymphocyte ratio to differentiate gangrenous from non-gangrenous appendicitis keeping histopathology as gold standard.

Study Design: Cross Sectional Validation Study.

Study Setting: Department of General Surgery, MTI-KTH, Peshawar.

Study Duration: 28-01-2021 – 28-07-2021

Subject and Methods:

This study was conducted on 148 patients with normal or inflamed appendix and gangrenous appendix. Patients having age between 18-60 Years of either gender were enrolled in the study. Patients with malignant diseases, current course of chemotherapy or radiotherapy, pregnancy, intraoperative diagnosis of intraabdominal pathology other than appendicitis, and presence of known liver diseases were excluded. Diagnostic accuracy of Gangrenous appendicitis on NLR was determined.

Results:

This study was conducted on 148 patients. The mean age of the patients was 40.03±12.60 years. According to the diagnostic accuracy of Gangrenous appendicitis on NLR, sensitivity was 82.3%, specificity was 57.1%, Positive predictive value was 66.13%, negative predictive value was 77.03% and diagnostic accuracy was 70.20%

Conclusion:

The diagnostic accuracy of neutrophil to lymphocyte ratio to differentiate gangrenous from non-gangrenous appendicitis keeping histopathology as gold standard was 70.20%.


Keywords: Neutrophil to Lymphocyte Ratio (NLR), Gangrenous Appendicitis, Histopathology, Diagnostic Accuracy

Pages: 1014-1018

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