International Journal of Advanced Multidisciplinary Research and Studies
Volume 3, Issue 3, 2023
Protective Role of Vitamin C Zinc against Toxicity Induced by Cadmium in White Rats
Author(s): Zainab Salim Alwan, Afyaa Sabah Nasir
The present study was conducted to determine the protective effects of zinc and vitamin C, individually or in combination with Cd, in order to monitor their ability to improve against cadmium-induced oxidative damage in albino rats. Through research, it was found that cadmium is a toxic element that harms liver tissue. Vitamin C and zinc have been shown to have an important protective role against the toxic effects of cadmium. The study was conducted on 40 male rats and it was divided into two periods for each period of five groups, each group containing four mice. The duration of the first period was 3 weeks, and the second period was 6 weeks. This study was conducted by biochemical criteria and blood analysis in affected albino rats administering a dose of cadmium with drinking water 10 mg/L individually for (3 weeks, 6 weeks) and evaluate the role of preventive measures. The results showed a significant decrease p < 0.05 in RBC, Hb and pcv in the cadmium-treated group when compared with the control group and a significant increase in WBC in the cadmium-treated group when compared to the control group for two weeks (3,6) For pcv, Hb, there were no significant differences p > 0.05 for the (cd + vt.c, cd + zinc, cd + vt.c + zinc) groups.
When compared with the control between the two periods (3,6) weeks, while WBC and RBC there were significant differences p<0.05 for the treated groups (cd+vt.c, cd+zinc, cd+vt.c+zinc) when compared with control, and when comparing between the two periods, the results showed that there were significant differences p<0.05 for the cadmium group compared with the treated groups (cd+vt.c, cd+zinc, cd+vt.c+zinc) for all blood parameters. Biochemical tests the levels of urea and creatinine in the rats treated with cadmium increased significantly (p 0.05) when compared to the control group and both periods, according to the hematological parameters. As for urea, there were significant differences, p<0.05, for the treatment groups (cd+vt.c, cd+zinc, cd+vt.c+zinc) compared with control and both periods. In terms of creatinine, there were significant differences between the treatment groups (cd+vt.c, cd+zinc, and cd+vt.c+zinc) and control group (p>0.05) for both times. For all biochemical parameters, the cadmium group's results showed statistically significant differences (p 0.05).Vitamin C is known as an element essential food for all kinds of animals. In other words, these vitamins have been shown to have a protective effect against toxicity caused by metals. In conclusion, this study showed that oral exposure to cadmium caused a decrease in biochemical and hematological activities in rats, and vitamin C had a reinforcing effect against toxicity that Mineral induced A natural antioxidant that prevents increased free radical production resulting from oxidative damage to lipids and lipoproteins in many tissues.
Keywords: Cadmium, Zinc, Vitamin C, Amelioration Potential
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